On the other hand, symptomatic malaria occurs during the blood stages when merozoites are released in the bloodstream and results in a cascade of inflammatory cytokines such as IL-6, IL-8, IL-10, IL-1, and IL-12 that are associated with a “cytokine storm” that is implicated in disease severity (Figure 1, Table 1) [59]. This evidence concerns the gene IL6 and malaria.