During 6 months follow up symptoms and ejection fraction (EF)% were improved and myocardial ischemia was reduced.78 In the same way, Kusumanto et al try to characterize the effect of intramuscular administration of VEGF gene-carrying plasmid (phVEGF165) on in 54 adult diabetic patients with critical limb ischemia. Here, VEGFA is linked to myocardial ischemia.