HIF1A and ischemic stroke: Result emphasize that Ad-HB-EGF can contribute to functional recovery via elevating angiogenesis and neurogenesis in animals model of ischemic stroke.75 In another study, a new protein transduction domain (Hph-1-GAL4; ARVRRRGPRR) was used to overexpress the hypoxia-inducible factor-1 alpha (HIF1A) and investigated it’s in vitro and in vivo effects on angiogenesis.