Fibrotic marker’s down-regulation induced by HGF-f, Compared to the control, resulted in enhanced arteriole density, and improved myocardial function in the MI rat’s model.97 Besides, in vitro and in vivo research indicated that VEGF/Ang2 could increase the formation of microvascular and vessel maturation in the blood vessel formation subcutaneous model.98 Paul et al in another study designed a new injectable Hydrogel to deliver the VEGF165 gene and graphene oxide nano complex for myocardial therapy. The gene discussed is VEGFA; the disease is myocardial infarction.