CASP9 and early-onset autosomal dominant Alzheimer disease: Apigenin significantly fettles spatial working memory and decreased degenerative neurons in hilus via complete blockade of caspase 9 and cytochrome c release in Aβ 25-35 induced rat model of Alzheimer disease. The finding suggested that apigenin can rescue the spatial working memory and neuronal degeneration via reversal of mitochondrial dysfunction.