CREB1 and Alzheimer disease: Apigenin restores AD associated learning and memory impairment via the suppression of the amyloidogenic process, alleviating the Aβ burden, restoring ERK/CREB/BDNF pathway, and through prevention of oxidative stress in APP/PS1 double transgenic mouse model of AD. The finding suggested that apigenin could be an alternative agent for the prevention of AD-associated symptoms.