Apigenin promotes the upregulation of NF-kB gene expression and inhibits the release of pro-inflammatory cytokines IL-l, TNF-α, and also prevents the reduction of BDNF and GDNF levels in rotenone-induced rat model of PD. Thus, the results suggested that apigenin could serve as an effective agent for the management of PD. The gene discussed is TNF; the disease is Parkinson disease.