Apigenin mitigates neuroinflammation and astrocytes integrity by the downregulation of IL-6, IL-1β expression, and upregulation of IL-10 in LPS induce in vitro model of neuroinflammation associated with Alzheimer disease. Thus, the finding suggested that apigenin could be a potential agent for the treatment of neurodegenerative diseases. Here, IL1B is linked to neurodegenerative disease.