SOD1 and Mental deterioration: Apigenin elevates body weight, improves cognitive dysfunction, reduces blood glucose, MDA content, and increases SOD level in the cerebral cortex and hippocampus in the streptozotocin-induced rat model of diabetes-associated cognitive dysfunction. Finding suggested that apigenin could be an effective therapeutic agent for diabetes-associated cognitive decline in rats via the suppression of apoptotic, nitric oxide, and oxidative stress pathways.