AP-SD prospers the nuclear translocation of Nrf2 and increases the expression of Nrf2 as well as target genes HO-1 and NQO-1. It also enhanced the activity of SOD and GSH-Px, and decreased the level of ROS and MDA in a mouse model of AMD. The finding suggested that AP-SD could be an effective compound for the treatment of AMD. This evidence concerns the gene SOD1 and age-related macular degeneration.