CREB1 and memory impairment: Apigenin rescues the behavioral impairments, cognitive deficits and increases the level of BDNF, cAMP, and CREB without altering seizure severity in pentylenetetrazole kindling associated behavioral and cognitive impairments in the mouse model. However, it also increases the serotonin level in the brain. The finding suggested that apigenin may be a potent therapeutic candidate to treat memory impairment and related diseases.