Apigenin shows a neuro-protective effect in the Drosophila model of PD through increasing GSH, dopamine content, life span and reducing the level of GST activity, MAO, lipid peroxidation, and caspase 3/9 in a dose-dependent manner. The study highlighted the neuroprotective potential of apigenin in PD. Here, CASP3 is linked to Parkinson disease.