Apigenin has several beneficial effects as an antioxidant, anti-inflammatory, blood pressure reduction, and chemo-preventive.3 Apigenin has an effect in the downregulation of IL-1β and TNF-α; also, it shows anti-inflammatory properties by attenuating the expression of COX-2 and iNOS.1 At the cellular level, apigenin acts as an inhibitor of several protein-tyrosine and serine-kinases.3 Apigenin has many pharmacological roles as antiphlogistic, antispasmodic, and antibacterial agent, anti-asthmatic, anti-parkinsonism agent (Table 1).4 This evidence concerns the gene TNF and Parkinson disease.