Apigenin significantly decreases early brain injury such as BBB disruption, brain edema, and cell apoptosis via the repression of NF-kB, TLR4, and their pro-inflammatory cytokines in the cortex in a rat model of subarachnoid hemorrhage. The finding suggested that apigenin could be protective against early brain injury. The gene discussed is TLR4; the disease is subarachnoid hemorrhage.