Apigenin shows a protective effect by the up-regulation of PPARγ expression, oxidative stress, inhibition of microglia, and NLRP3 activation, which subsequently down-regulate the production of IL-1β and IL-18 in a chronic unpredictable mild stress rat model of depression. Results suggested that it may be beneficial for the management of depression. Here, NLRP3 is linked to depressive disorder.