Apigenin exerts neuroprotective effect via maintaining redox balance by increasing cellular superoxide dismutase, glutathione level, and reduced ROS generation; obstructing p38 MAPK, MAPKAP kinase-2, heat shock protein 27 and c-jun N-terminal signaling pathways and reduced neuronal apoptosis in a copper-mediated β-amyloid neurotoxicity cell model of AD. The finding suggested that it could be a potential therapeutic for AD. Here, MAPKAPK2 is linked to Alzheimer disease.