LAMB3 encodes β3, one of the three chains of Laminin-332, which have various functions in invasion, migration and progression of metastasis in different cancers.8 The MMP-7 can produce a cleaved fragment of 90 kD originated from LAMB3 which can induce the migration of colon carcinoma cells.9 Moreover, during the pulmonary metastasis early arrest of tumor cells happens through the interaction of α3β1 integrin with LN-332.10 The gene discussed is LAMB3; the disease is colon carcinoma.