CD4 and HIV-1 infection: It also down regulates the cancer cell replication, relocation, cell-cycle arrest at G2/M phase and decreased E-selectin expression, JAK/STAT/NF-κB signalling pathway.5,27,30,31Anti-viral studies of andrographolide shows enhancement of CD4+ T cells against HIV-1 infection and blocks dysregulation of cell cycle.32 They block the HIV virus by inhibiting HL2/3 adhesion to TZM-bl cells through andrographolide association between gp20 and CD4, CCR5, CXCR4.33 Other studies show down-regulation of herpes simplex virus, Epstein-Barr virus, Dengue virus 1, flavivirus and Pestivirus by andrographolide.