K1F14 is a tumor inhibitor gene that prevents cell migration and induce cell apoptosis and its knockdown is found increases breast cancer subjects.34KIF14 plays an important role in drug resistance by enhancing cell proliferation through Akt1 pathway which with decreased activation lowers the level of Akt and affects the P13K/ Akt signaling that controls the apoptosis pathway. The gene discussed is AKT1; the disease is breast carcinoma.