Hyperactivity of MAPK signalling by the c- ras, b- raf, MEK 1⁄2mutation is commonly seen in many human cancer cells including breast cancer.11 MAPK/ERK pathway regulates cell cycle and cell proliferation having a crucial role in cancer treatment especially in triple negative breast cancer cases.12 Heterodimerization of RAF kinase cause the activation of ERK pathway and drug resistance. This evidence concerns the gene BRAF and cancer.