Pro apoptotic activity of this gene is inhibited by BFGF, which leads to the end of apoptosis.42ASK1 gene’s level is related with CLDN6 expression and over expression of CLDN6 is linked with breast cancer chemo resistance through GSTP1 its activity is regulated by p53.43 in the treatment of hormone sensitive breast cancer, tamoxifen resistance is a clinical obstacle. The gene discussed is CLDN6; the disease is breast cancer.