This study focuses on SPARC, THBS2, COL11A1, COL1A1, COL1A2, COL3A1, SERPINH1, and PLAU proteins released into the extracellular matrix that provided various biomarkers for non-invasive to invasive stages of pancreatic cancer, which require more extensive studies to investigate and find more precise mechanisms of these proteins. This evidence concerns the gene THBS2 and familial pancreatic carcinoma.