This study focuses on SPARC, THBS2, COL11A1, COL1A1, COL1A2, COL3A1, SERPINH1, and PLAU proteins released into the extracellular matrix that provided various biomarkers for non-invasive to invasive stages of pancreatic cancer, which require more extensive studies to investigate and find more precise mechanisms of these proteins. Here, COL3A1 is linked to familial pancreatic carcinoma.