Generally, 19 cancer-regulated pathways with P<0.05 were detected in KEGG, which revealed that the most significant up-regulated pathways were focal adhesion (P=7.76E-21), ECM-receptor interaction (P=6.6E-13), HIF-1 signaling pathway (P=1.34E-08), TNF signaling pathway (P=6.69E-08), PI3K-Akt signaling pathway (P=9.78E-08) and apoptosis (P=1.05E-06). Here, TNF is linked to cancer.