The S1 subunit achieves attachment of the virus to the host cell, and S2 subunit enables fusion of the SARS-CoV-2 and host cellular membranes.5 The S protein of SARS-CoV-2 interacts directly with human angiotensin-converting enzyme 2 (hACE2) allowing infection of the host cell with SARS-CoV-2.3,26–30 Due to the important role in the S protein for SARS-CoV-2 infection, it has been the target of vaccine candidates. The gene discussed is PROS1; the disease is infection.