A previous meta-analysis by Zhen et al. [4], which included studies between 2008 and 2012, on the comparative role of CA-125 and HE4 as a biomarker in ovarian cancer revealed that the pooled sensitivity (95% CI) for HE4 and CA-125 were 0.74 (0.72-0.76) and 0.73 (0.72-0.76), respectively, which is lower than our updated meta-analysis. Here, WFDC2 is linked to ovarian cancer.