WFDC2 and neoplasm: The currently available evidence of HE4, both serum and urine, as a tumor marker for the diagnosis and differentiation of ovarian masses is summarized in our meta-analysis. Figure 5 and Figure 9 show the forest plot of pooled sensitivity and pooled specificity of serum and urine HE4, respectively, for the diagnosis of ovarian cancer in our meta-analysis, which endorses the diagnostic efficacy of serum and urine HE4.