Region of residence, BMI, albumin, transferrin saturation, ferritin, vitamin D3, sodium, calcium, creatinine, urea, hemoglobin, HbA1c, number of prescribed drugs, substance dependence, PGS, SWT, LPA, SRE, UWL, and ESR were independent significant predictors of frailty. This might be the first study to analyze the predictors of frailty in Uttarakhand, India. The gene discussed is ALB; the disease is substance dependence.