Diabetes complications are directly related to duration of diabetes and poor glycemic control.5 Uncontrolled hyperglycemia of DM results in non-enzymatic alterations of many plasma proteins e.g. glycation of serum albumin (which represents about 80% of the total of glycation in plasma)10 causes very harmful effects both in development as well as in progression of diabetic complications.19 Advance glycation end products (AGEs) dominate in the vasculature of patients of DM20 and are believed to play an important role in the pathogenesis of diabetic retinopathy.21 The gene discussed is ALB; the disease is diabetes mellitus.