SIRT1, belonging to the histone acetylase family, is expressed in cells such as renal tubular epithelial cells and podocytes, with multiple physiological functions including resisting apoptosis, regulating energy metabolism, reducing cell injury, anti-inflammation and maintaining normal organ functioning.15 In addition, it has certain diagnostic value for diabetic complications.16 The occurrence of DN is related to podocyte injury. The gene discussed is SIRT1; the disease is liver dysplastic nodule.