In terms of age (p=0.753), previous amputation history (p=0.884), alcohol use (p=0.696), diabetes duration (p=0.932), white blood cell count (p=0.683), plasma albumin (p=0.752), hsCRP (p=0.492), Hb (p=0.662), HbA1c (p=0.179), LDL-C (p=0.892), and medical comorbidities including hypertension (p=0.338), CAD (p=0.183), CRI (p=0.645), retinopathy (p=0.564) and sequelae of cerebral infarction (p=0.495), there were no significant differences between the two groups (Table-II). This evidence concerns the gene ALB and retinal disorder.