A retrospective study conducted in India reported an endophthalmitis rate of 0.050% for anti-VEGF injections administered in ambulatory surgical units which included both in-office setting as well as an OR one.21 Meanwhile, Tabandeh et al, a retrospective study, did not report a significant difference in the incidence of endophthalmitis between the two settings.22 This evidence concerns the gene VEGFA and endophthalmitis.