TXA can thus inhibit the combination of tyrosinase and tyrosine, and reduce the production of melanin.11 At present, a large number of studies have confirmed the safety and reliability of TXA in the treatment of melasma.3,12 Ebrahim HM et al13 studied the treatment of melasma by intradermal injection of TXA and TXA microneedle. Here, TYR is linked to freckles.