NR1D1 and immune system disorder: REV-ERBα and RORs have been implicated in various diseases including metabolic diseases, immune diseases, and cancers.53,61,86,87 REV-ERBα and RORs show altered expressions and disrupted rhythms during disease development.88–90 Furthermore, alteration of REV-ERBα and RORs affects the organism susceptibility to diseases in both humans and mice and is involved in many pathways associated with pathological processes and diseases.61,87,90,91–93