We observed 24 ABH antigen synthesis‐related genes in which five genes (FUT1, FUT2, FUT3, B3GNT3, and B3GNT2) were up‐regulated and three genes (ST3GAL3, ST3GAL4, and B3GALT2) were down‐regulated in ovarian tumor tissue versus adjacent tissues in all samples. The gene discussed is ST3GAL4; the disease is ovarian neoplasm.