Although the mechanism of action of PRF is unclear, it is known to regulate TGF-β and cytokine levels, which are key factors in IPF progression (Conte et al., 2014), to inhibit fibroblast proliferation, collagen synthesis, and release of collagenases (Hilberg et al., 2012; Macías-Barragán et al., 2010; Schaefer et al., 2011). This evidence concerns the gene TGFB1 and idiopathic interstitial pneumonia.