NFKB1 and magnesium deficiency: Secondly, magnesium deficiency can lead to the activation of the inflammatory system,57 possibly through the activation of NF‐kB (including transcriptional programs that lead to the development of pro‐inflammatory phenotypes) leading to injury and dysfunction of vascular endothelium,58 which then result in the occurrence and development of atherosclerotic lesions,59 then further triggers vascular calcification and promotes lipid accumulation in vascular plaques.60