TF and Parkinson disease: The TF activity analysis of the significant SN genes performed with Dorothea [43] reported 40 differentially activated TFs (adjusted p-value < 0.05), with 29 more activated in male PD patients (NES < 0) and 11 more activated in female PD patients (NES > 0) (Fig. 6 and Additional file 3: Table S3).