IFITM3 and early-onset autosomal dominant Alzheimer disease: In Alzheimer's disease, inflammatory cytokines induce IFITM3 expression in neurons and astrocytes; IFTM3 then binds to γ-secretase to upregulate activity, increasing the production of amyloid-β (the main component of the amyloid plaques found in Alzheimer's disease patients) [65, 66].