GPX4 and clear cell renal carcinoma: Numerous studies have explored the relationship between ferroptosis and malignant tumors at the genetic level, such as trying to treat renal clear cell carcinoma by glutathione peroxidase 4 (GPX4)-dependent ferroptosis [13], inhibiting ALOX5 may promote ferroptosis in pancreatic ductal adenocarcinoma [14], SLC7A11-mediated cystine uptake inhibits ferroptosis in breast cancer cells [15] etc. Based on a large number of studies, some researchers have summarized the related literature on ferroptosis, and classified the genes involved into a database [16].