There is a close association between IL-23 and IL-17A in AILI, APAP induced injury-related liver inflammation via the HMGB-1-TLR4-IL-23-IL-17A axis, in which IL-23 produced by HMGB-1-TLR4-mediated macrophages is required for IL-17A production by γσ T cells [67]. This evidence concerns the gene TLR4 and Hepatitis.