Genetic variation in CACNA1A is associated with autosomal dominant episodic ataxia, type 2 (EA2, MIM# 108500), epileptic encephalopathy (EIEE42, MIM# 617106), migraine (FHM1, MIM# 141500), and spinocerebellar ataxia (SCA6, MIM# 183086), and is defined by incoordination, imbalance, dizziness, migraines, tinnitus, dysarthria, hemiplegia, and muscle cramping. The gene discussed is CACNA1A; the disease is cerebellar ataxia.