In addition, another sensitivity analysis which excluding subjects with CABG, stroke and peripheral arterial disease (n = 1686), showed that high Lp(a) remains an independent predictor of MACCE in this population (adjusted HR 1.238, 95%CI 1.016–1.509, p = 0.035) after adjusting for potential confounding factors (shown in Supplementary Table 2). The gene discussed is LPA; the disease is Stroke.