Large prospective epidemiological studies confirmed that Lp(a) is an independent and causal risk factor for a variety of atherothrombotic disorders, most notably CHD through proatherogenic, prothrombotic and proinflammatory effects, it is also related with occurrences of peripheral arterial disease, myocardial infarction(MI), and ischemic stroke [4–6]. The gene discussed is LPA; the disease is myocardial infarction.