They performed a retrospective study on the expression of bikunin, uPA and CD68 (macrophages) in 89 tumor specimens, evidencing that i) bikunin localized mainly in the cytoplasm of tumor-infiltrating macrophages, ii) its levels were inversely related with those of uPA, iii) low expression of bikunin was inversely related with lymph node metastasis and disseminated peritoneal metastasis. The gene discussed is PLAU; the disease is neoplasm.