PLAU and bacterial urinary tract infection: Furthermore, they found that incubation of human chondrosarcoma cell line HCS-2/8 with an anti-LP antibody or soluble chondroitin 4-sulfate, by blocking the binding to either UTI-BP40 or UTI-BP45, independently abrogated suppression by UTI of phorbol ester-induced uPA expression, therefore demonstrating that the concurrent binding to both BPs by UTI is necessary to inhibit uPA expression.