Recently, Sekikawa et al., by immunohistochemical analysis on 95 oral squamous cell carcinoma specimens, observed the underexpression of AMBP precursor (using a monoclonal antibody raised against a full-length recombinant AMBP) significantly associated with a high metastatic potential to cervical lymph nodes and a poor overall survival [69]. The gene discussed is AMBP; the disease is oral cavity squamous cell carcinoma.