SMYD3 and obesity due to melanocortin 4 receptor deficiency: SMYD3 (SET and MYND domain containing 3), which methylates various histone and non-histone targets (Bottino et al. 2020), is an obesity-related gene and has been proposed as one of the candidates for body mass index in pigs and humans (Zhou et al. 2016), suggesting that PAS-SNPs in Smyd3 may influence differential epigenetic regulation between the two lines.