Compared to WT, adult Angptl2-KD mice show the onset of a mild LV dysfunction, with reduced echocardiographic systolic and diastolic parameters, but still in the normal range, and without an increased expression of heart failure markers Nppa and Nppb. We showed that ≅70–75% of Angptl2-KD mice develop mild AVS and ≅ 5% exhibit a more severe AVS phenotype. Here, ANGPTL2 is linked to heart failure.