CD226 and COVID-19: While unpaired at the cellular level, CyTOF and scRNA-seq profiling of whole blood from the same COVID-19 patients was able to identify significantly decreased expression of activating receptors DNAM-1 and NKG2D protein in activated NK cells from severe COVID-19 samples compared with healthy, but no changes in levels of their transcripts [18], which provides an example for the importance of multimodal analyses as different conclusions could be had when focusing on one measurement for analyses.