Moreover, the Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis revealed that the rat sarcoma (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase kinase (MEK)/extracellular regulated protein kinases (ERK) signaling pathway was obviously activated after knocking down LRP3 (Fig. 6i). This evidence concerns the gene RAF1 and fibrosarcoma.