Correlation analysis showed that upregulated PRSS22 expression was strongly correlated with molecular classification (Fig. 1J), positive LNM (P = 0.0021), clinical stage (P = 0.0080), and histological grading (P = 0.0133), whereas there was no correlation between PRSS22 expression and other characteristics such as age, tumor size, as well as the expression of ER, PR, and HER2 (Table 1). Here, PRSS22 is linked to neoplasm.