SMAD6 and coronary artery disorder: Remarkably, in six out of the 14 families a variant-positive SMAD6 carrier without RUS but with skeleton-, skull-, or CHD-related features9,13 was reported: two affected individuals from two families displayed cervical fusion or caudal vertebrae dysplasia, two patients from two families exhibited with premature closure of anterior fontanel, frontal bossing and plagiocephaly or solely plagiocephaly, one subject presented with polydactyly and, finally, one affected had patent ductus arteriosus together with mitral regurgitation.