ATOX1 and neoplasm: Similarly, the Cu chaperone ATOX1 has also been found to serve as a modulator of angiogenesis, the depletion of Atox1 inhibit the migration of vascular smooth muscle cell that is stimulated by platelet-derived growth factor (PDGF), suggesting that ATOX1 likely plays a role in vascular remodeling and tumor angiogenesis.173