To the best of our knowledge, CSF or plasma α‐MSH and neurotensin levels have not been measured in psychiatric disorders, while α‐MSH and neurotensin have been associated with metabolic syndrome in patients with schizophrenia, BD, and MDD15 and reward‐related behavior in patients with schizophrenia,20 respectively, and may have a potential role in the pathophysiology of the patients. The gene discussed is NTS; the disease is metabolic syndrome.