Unlike our hypotheses, our data showing the absence of alteration or correlation regarding five neuropeptides in patients with schizophrenia, BD, or MDD do not support previous reviews suggesting the involvement of α‐MSH,15 β‐endorphin,16, 17 neurotensin,20 and oxytocin25, 26 in the pathology of psychiatric disorders although metabolic syndrome, reward‐related behavior, and social anxiety or socio‐emotional behavior were not assessed in this study. This evidence concerns the gene NTS and psychiatric disorder.