Numerous studies have revealed that the abnormal neuronal function, overactivated microglia, and excessive neuroinflammatory reactions are involved in the onset of depression.[7, 8] Emerging evidences have now implicated astrocyte dysfunction in the pathogenesis of MDD.[9] Activated astrocytes produce pro‐inflammatory cytokines such as interleukin IL1β, TNFα, which are key to the induction of depressive symptoms. This evidence concerns the gene IL1B and major depressive disorder.