To examine whether Mysm1 may play a role in the pathophysiology of depression, we exposed male C57BL/6N mice to 2 weeks of chronic restraint stress (CRS) to mimic depression.[18] Depressive‐like phenotypes in CRS mice were validated by the longer immobility time in the tail suspension test (TST) and forced swimming test (FST) and a lower score in the coat score (CS) assay (Figure S1, Supporting Information). Here, MYSM1 is linked to major depressive disorder.