A previous report in support of our data demonstrated that aspirin was able to suppress Mysm1 expression in diabetic animals.[26] Preclinical, pharmacoepidemiologic and pilot clinical trial data have suggested that aspirin has therapeutic potential for depression due to its anti‐inflammatory properties.[55] Here, we found that microinjection of aspirin into the MHb alleviated depressive‐like behavior and restored mitochondrial structure in vivo in mice. This evidence concerns the gene MYSM1 and depressive symptom measurement.