MYSM1 and central nervous system cancer: Several studies have reported that Mysm1 can interact with the p53 axis in the process of tissue development.[27, 52] p53 has been shown to activate the AMPK pathway and suppress the mTOR pathway in glioma cells.[53] Interestingly, the increased phosphorylation of p53 was observed with Mysm1 knockdown in astrocytes.