For clinical relevance, we extended our analysis to published data from knee synovial tissues of osteoarthritis patients,13 28 29 which similarly showed that THY1-PRG4+CLIC5+ FLS exhibited SOX5, FOXO1 and CREB5 regulon activity (figure 6F, online supplemental figure 25). The gene discussed is CREB5; the disease is osteoarthritis.