ATG5 and neoplasm: Therefore, NAD(H) decline is independent of the previously proposed purine/pyrimidine depletion mechanism of cell death in autophagy-deficient tumor-derived cells.19 However, nucleoside supplementation prevented the dissipation of ΔΨm in respiring Atg5−/− MEFs, which would explain the rescue of cell death (Figures S7D and S7E).