Since KLK8is typically co-expressed with KLK6 in multiple disease contexts,including in pancreatic cancer,16,29−31 initial probe development focused on an ABP selective toward KLK6over KLK8, a challenging objective in view of their common trypsin-likespecificity for Lys/Arg at P1. This evidence concerns the gene KLK8 and familial pancreatic carcinoma.