AKT1 and acute myeloid leukemia: Although it is hard to reveal the cell-line-dependent regulation of cell cycle arrest and completely map the mechanisms of actions in AML, our studies, together with KEGG pathway analysis, demonstrated the capacity of FD268 in suppressing cell proliferation and inducing apoptosis on AML through inhibition of PI3K/Akt/mTOR signaling pathway (Fig 9).