Univariate analysis showed that among ACLF patients, age, sex, presence of type 2 diabetes mellitus (T2DM) and bacterial infection did not predict short-term death, whereas creatinine, INR, bilirubin, lactate, bicarbonate, albumin, ACLF grading, and prognostic models (CLIF-C OF, CLIF-C ACLF, ALBI, MELD, MELD-Na, and CTP scores) were parameters associated with both 30-day and 90-day mortality rates. The gene discussed is ALB; the disease is diabetes mellitus.