To determine the full extent of the mechanism underpinning the epigenetic repression of GPRC5A, we examined the roles of DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor 5-Aza-2-dc and pan-histone deacetylase (pan-HDAC) inhibitor SAHA in NSCLC cell lines. The gene discussed is GPRC5A; the disease is non-small cell lung carcinoma.