Exome sequencing of the 786-O, A498, SLR22, and RCC4 human ccRCC cell lines, as well as analyses of mutations in 769-P cells published in the DepMap-CCLE database, revealed that all cell lines harbored VHL mutations as well as mutations in 1 or more of the PBRM1, BAP1, SETD2, or KDM5C genes or 1 of the DNA damage– or DNA repair–related genes ATM, TP53, MSH6, PMS1, or POLE (Supplemental Figure 1A and Supplemental Data 3). Here, POLE is linked to nonpapillary renal cell carcinoma.