Similar GAGE analyses were conducted using RNA-Seq data from Vhl/Trp53/Rb1-deficient mouse tumors versus normal renal cortex (Figure 1D) and from matched normal and ccRCC tumor samples from The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) database (Figure 1E). The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.