Correlation of the strength of the DNA repair signature with mRNA expression of the proliferation markers MKI67 (Supplemental Figure 2B) or PCNA (Supplemental Figure 2C), or with enrichment of an mRNA signature of proliferation-associated genes (Supplemental Figure 2D), revealed a positive correlation between proliferation and the enrichment of the DNA repair signature, consistent with proliferation-associated DNA damage as being one contributor to the enrichment of mRNA signatures of DNA damage in ccRCC. This evidence concerns the gene PCNA and nonpapillary renal cell carcinoma.