Increased expression of several genes previously reported to be associated with CML stem cells and TKI resistance, including Myc, Mpl, Stat3, Stat5a, Stat6, and Ctnnb, was seen in CML c-KITlo versus c-KIThi LT-HSCs (Figure 2B) (27–34). The gene discussed is STAT6; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.