MYC and chronic myelogenous leukemia, BCR-ABL1 positive: Inflammatory signaling, glycolysis, and hypoxia signatures were enriched in both normal and CML c-KITlo LT-HSCs compared with their c-KIThi LT-HSC counterparts, whereas OXPHOS, Myc, and cell cycle signatures were enriched in both normal and CML c-KIThi LT-HSCs compared with their c-KITlo LT-HSC counterparts (Figure 2F).