Therefore, deletion of Scf reduces c-KITlo LT-HSCs, total LT-HSC and progenitor numbers, and BM cellularity in normal mice, but increases c-KITlo LT-HSCs and total LT-HSCs in CML mice, while reducing splenic progenitors and circulating myeloid cells. Here, KITLG is linked to chronic myelogenous leukemia, BCR-ABL1 positive.