We studied c-KIT expression in CML LT-HSCs using a well-characterized transgenic Tg(Tal1-tTA)19Dgt × Tg(tetO-BCR/ABL1)2Dgt (Scl-tTA BCR-ABL) mouse model of CML. This evidence concerns the gene KIT and chronic myelogenous leukemia, BCR-ABL1 positive.