GSEA comparing CML c-KITlo and CML c-KIThi LT-HSCs showed that the latter were enriched for gene signatures for inflammatory signaling (IL-6/JAK/STAT3, IL-2/STAT5, and TNF-α/NF-κB signaling; inflammatory response); TGF-β, Wnt/β-catenin, and Hedgehog signaling; hypoxia; and glycolysis, whereas CML c-KIThi LT-HSCs were enriched for OXPHOS, Myc and E2F targets, and DNA repair (Figure 2C). Here, STAT5A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.