Significantly reduced numbers of LT-HSCs but significantly higher numbers of ST-HSCs, MPPs, and total cells was seen after culture of CML c-KITlo LT-HSCs with SCF compared with normal c-KITlo LT-HSCs (Figure 5, B–E). The gene discussed is KITLG; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.