Further analysis of genes contributing to inflammatory signaling profiles in CML c-KITlo LT-HSCs revealed increased expression of Csf1, Tnfrsf21 (DR6), IL-10 receptor, CSF3 (G-CSF) receptor, and IFN-α receptor, together with increased expression of Stat3, Stat5, Socs3, NF-kB, and c-Myc (Figure 2D and Supplemental Figure 2B). Here, SOCS3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.