MAPK8 and neoplasm: In scrib−/−/RasV12 clones, JNK and Yki cooperate to upregulate the amino acid transporter Juvenile hormone Inducible-21 (JhI-21, an L-amino acid transporter 1 LAT1 homolog), which activates TOR-S6 signalling by uptaking leucine to promote tumour growth [65] (Figure 3b).