Noncarriers of KL-VS heterozygosity in the control group showed significantly higher median CSF Klotho levels compared with the AD group (control group, 1186.9 pg/mL [range, 520.4-1723.3 pg/mL]; AD group, 1119.1 pg/mL [range, 698.2-1592.7 pg/mL]; P = .01), whereas no significant difference was found among KL-VS heterozygosity carriers (eFigure 1 in the Supplement). The gene discussed is KL; the disease is Alzheimer disease.