Although no significant difference was found in the control group, median plasma Klotho levels in the AD group were significantly higher among KL-VS heterozygosity carriers compared with noncarriers (carriers, 910.9 pg/mL [range, 501.7-1563.5 pg/mL]; noncarriers, 790.1 pg/mL [range, 351.9-2733.8 pg/mL]; P = .002). Here, KL is linked to Alzheimer disease.