KL and amyloidosis: This was evident in a recent study that had to double the sample size to identify a significant association between KL-VS heterozygosity and amyloid burden.13 Together, the association of the CSF Klotho protein levels, but not the genetic variant KL-VS heterozygosity, with levels of amyloid indicates that the results are mediated more robustly by the protein and not indirectly by the genotype that is correlated with higher protein levels.