KLK3 and cancer: Total spending on initial PSA cancer screening for our sample population was $3.8 million, with an additional $22.0 million spent on follow-up services: $1.8 million on additional (ie, second or more) PSA tests, $4.2 million on prostate biopsy, $0.7 million for imaging services, $0.6 million on radiation therapy, and $14.7 million on prostatectomy.