Although we did not detect differences in the number or percentage of monocytes or macrophages in the intestine (Tamoutounour et al., 2012) during DSS colitis on day 2 (Fig. S5 E), in vivo Tnf transcription by LP macrophages of TgVil1-Itln1 mice was greater than that of wild-type littermates (Fig. 4 F). Here, ITLN1 is linked to colitis.