ITLN1 and inflammatory bowel disease: To deepen our understanding of the relationship between ITLN1 and IBD, we created a loss of function mouse model (Itln1−/− mice) and a model with forced expression of ITLN1 under the Villin-1 promoter (TgVil1-Itln1 mice), recapitulating the elevated colonic expression of ITLN1 observed in humans with UC.