ITLN1 and colitis: Overexpression of ITLN1, as occurs in patients with UC, increased the vulnerability of the TgVil1-Itln1 mice to chemically induced colitis and T cell–mediated colitis, consistent with the known role of bacterial penetration of the mucus barrier in predisposing to intestinal inflammation (van der Post et al., 2019; Johansson et al., 2008; Johansson et al., 2010; Johansson et al., 2011; Van der Sluis et al., 2006; Vaishnava et al., 2011; Propheter et al., 2017; Brasseit et al., 2016).