To validate these results in the context of rotavirus infection, rSA11 viruses were generated that expressed NSP1 with a C-terminal truncation of 98 residues (rSA11-NSP1-ΔC98) or with a C42A RING mutation (rSA11-NSP1-C42A) (Fig. 10C). The gene discussed is SH2D3A; the disease is Rotavirus infection.