BACE1 and Alzheimer disease: BACE1-AS is also able to bind to the cytoplasmic RBP HuD (ELAVL4) (Figure 3a), which increases the stability of BACE1-AS itself as well as that of BACE1 and APP mRNAs, thereby coordinating several steps that converge on the generation of amyloidogenic plaques in AD brain [70].