it is important to note that both SARS-CoV-2 (main target cell Angiotensin Converting Enzyme-2 (ACE2)), the YF virus, and other CoVs collectively limit the activities of the cell surface, endosomal, and cytosolic pattern recognition receptor (PRRs) responses to pathogen-associated molecular patterns (PAMPs) that trigger inflammatory responses and programmed cell death, which limits viral infections and clearances, thus enabling the possibility of viral coinfection [40]. Here, ACE2 is linked to viral infectious disease.