PLAT and stroke disorder: Considering that the assessment of the global burden of small vessel disease (SVD), as reflected by both white matter changes and pre-existing lacunar infarcts, may constitute a more precise marker with valuable prognostic potential in terms of clinical outcome and hemorrhagic complications following IVT among stroke patients, Arba et al. [48] investigated the association between detectable on baseline CT LA and lacunes and subsequent response to IV tPA.